If only one number is given it refers to the initial estimate, with two the lower bound and initial estimate. The first number is the lower boundry, the second the initial estimate and the third the upper boundry. The initial estimates of THETAs and boundries ETAs are the individual deviations from the population estimates.Ĭovariates, scaling and other calculations can be defined here as well. These subroutines have their own requirements concerning PK parameters.įor an overview of available closed form subroutines see hier. The subroutine determines what model will be used through the choice of ADVAN and TRANS subroutines. Make sure that if the data contains a header it is preceded by the ignore symbol. Ignore refers to the symbol set in front of a row in the dataset that NONMEM should ingore. csv), the file should be present in the same folder. The data section defines the name of the dataset (including. $INPUT CENSOR AORTA=DROP ID DATE=DROP TIME AMT DV EVID MDV
Note that NONMEM will look for the required items in the input. If a column is not to be read by NONMEM it should be explicitely mentioned and followed by '= DROP'. It does not look at names it will count columns and therefore have to be specified in the right order. The input section refers to the dataset in what order the columns appear. everything after will be seen as comment. General info: The ' ' indicates a comment. The NONMEM model file Description and explanation of the basic NONMEM database items.